Network analysis of aging acceleration reveals systematic properties of 11 types of cancers

@inproceedings{Xia2019NetworkAO,
  title={Network analysis of aging acceleration reveals systematic properties of 11 types of cancers},
  author={Xiaoqiong Xia and Mengyu Zhou and Hao Yan and Sijia Li and Xianzheng Sha and Yin Wang},
  booktitle={FEBS open bio},
  year={2019}
}
Cancers are known to be associated with accelerated aging, but to date, there has been a paucity of systematic and in-depth studies of the correlation between aging and cancer. DNA methylation (DNAm) profiles can be used as aging markers and utilized to construct aging predictors. In this study, we downloaded 333 paired samples of DNAm, expression and mutation profiles encompassing 11 types of tissues from The Cancer Genome Atlas public access portal. The DNAm aging scores were calculated using… CONTINUE READING

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