Network Topologies and Convergent Aetiologies Arising from Deletions and Duplications Observed in Individuals with Autism

@inproceedings{Noh2013NetworkTA,
  title={Network Topologies and Convergent Aetiologies Arising from Deletions and Duplications Observed in Individuals with Autism},
  author={Hyun Ji Noh and Chris Paul Ponting and Hannah C. Boulding and Stephen Meader and Catalina Betancur and Joseph D. Buxbaum and Dalila Pinto and Christian R Marshall and Anath Christopher Lionel and Stephen W. Scherer and Caleb Webber},
  booktitle={PLoS genetics},
  year={2013}
}
Autism Spectrum Disorders (ASD) are highly heritable and characterised by impairments in social interaction and communication, and restricted and repetitive behaviours. Considering four sets of de novo copy number variants (CNVs) identified in 181 individuals with autism and exploiting mouse functional genomics and known protein-protein interactions, we identified a large and significantly interconnected interaction network. This network contains 187 genes affected by CNVs drawn from 45% of the… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 8 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 29 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 68 references

Similar Papers

Loading similar papers…