Network Oscillations Generated by Balancing Graded Asymmetric Reciprocal Inhibition in Passive Neurons

  title={Network Oscillations Generated by Balancing Graded Asymmetric Reciprocal Inhibition in Passive Neurons},
  author={Yair Manor and Farzan Nadim and Steven Epstein and Jason T. Ritt and Eve Marder and Nancy J. Kopell},
  journal={The Journal of Neuroscience},
  pages={2765 - 2779}
We describe a novel mechanism by which network oscillations can arise from reciprocal inhibitory connections between two entirely passive neurons. The model was inspired by the activation of the gastric mill rhythm in the crab stomatogastric ganglion by the modulatory commissural ganglion neuron 1 (MCN1), but it is studied here in general terms. One model neuron has a linear current–voltage (I–V) curve with a low (L) resting potential, and the second model neuron has a linear current–voltage… 
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A reduced mathematical model is developed to examine how the synaptic interactions involving two projection neurons can produce and shape the activity of the gastric mill CPG in the crab stomatogastric nervous system and shows that feedback to projection pathways may provide additional mechanisms for the generation of motor activity.
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Ionic conductances underlying the activity of interneurons that control heartbeat in the medicinal leech
  • E. Arbas, R. Calabrese
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1987
The sag of HN neurons with injected currents revealed a time-dependent change in membrane potential, whereby initial maximum hyperpolarization was followed by a “sag” in potential towards more depolarized values, which may contribute to the escape of these neurons from synaptic inhibition.