Network Mendelian randomization: using genetic variants as instrumental variables to investigate mediation in causal pathways

@inproceedings{Burgess2015NetworkMR,
  title={Network Mendelian randomization: using genetic variants as instrumental variables to investigate mediation in causal pathways},
  author={Stephen Burgess and Rhian M. Daniel and Adam S. Butterworth and Simon Giles Thompson},
  booktitle={International journal of epidemiology},
  year={2015}
}
BACKGROUND Mendelian randomization uses genetic variants, assumed to be instrumental variables for a particular exposure, to estimate the causal effect of that exposure on an outcome. If the instrumental variable criteria are satisfied, the resulting estimator is consistent even in the presence of unmeasured confounding and reverse causation. METHODS We extend the Mendelian randomization paradigm to investigate more complex networks of relationships between variables, in particular where some… CONTINUE READING