Network Disruption and Cerebrospinal Fluid Amyloid-Beta and Phospho-Tau Levels in Mild Cognitive Impairment.

@article{Canuet2015NetworkDA,
  title={Network Disruption and Cerebrospinal Fluid Amyloid-Beta and Phospho-Tau Levels in Mild Cognitive Impairment.},
  author={Leonides Canuet and Sandra Pusil and Mar{\'i}a Eugenia L{\'o}pez and Ricardo Bajo and Jos{\'e} Angel Pineda-Pardo and Pablo Cuesta and Gerardo G{\'a}lvez and Jos{\'e} M. Gaztelu and Daniel Lourido and Guillermo Garc{\'i}a-Ribas and Fernando Maest{\'u}},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2015},
  volume={35 28},
  pages={
          10325-30
        }
}
UNLABELLED Synaptic dysfunction is a core deficit in Alzheimer's disease, preceding hallmark pathological abnormalities. Resting-state magnetoencephalography (MEG) was used to assess whether functional connectivity patterns, as an index of synaptic dysfunction, are associated with CSF biomarkers [i.e., phospho-tau (p-tau) and amyloid beta (Aβ42) levels]. We studied 12 human subjects diagnosed with mild cognitive impairment due to Alzheimer's disease, comparing those with normal and abnormal CSF… CONTINUE READING

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