Network-Based Relating Pharmacological and Genomic Spaces for Drug Target Identification

@inproceedings{Zhao2010NetworkBasedRP,
  title={Network-Based Relating Pharmacological and Genomic Spaces for Drug Target Identification},
  author={Shiwen Zhao and Shao Li},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND Identifying drug targets is a critical step in pharmacology. Drug phenotypic and chemical indexes are two important indicators in this field. However, in previous studies, the indexes were always isolated and the candidate proteins were often limited to a small subset of the human genome. METHODOLOGY/PRINCIPAL FINDINGS Based on the correlations observed in pharmacological and genomic spaces, we develop a computational framework, drugCIPHER, to infer drug-target interactions in a… CONTINUE READING