Netrin signaling leading to directed growth cone steering.

  title={Netrin signaling leading to directed growth cone steering.},
  author={Jennifer E. Round and Elke Stein},
  journal={Current opinion in neurobiology},
  volume={17 1},
In the developing nervous system, nerve cells and axons respond to various attractive and repulsive guidance cues while traveling to their final destination. Netrins are bifunctional guidance cues that attract several classes of axons but repel others. The response of an axon to netrins is dictated by the composition of netrin receptors on the cell surface and the internal state of the growth cone. Recent analyses have identified several signal transduction pathways that contribute to netrin… CONTINUE READING
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