Netrin-4 overexpression suppresses primary and metastatic colorectal tumor progression.

@article{Eveno2013Netrin4OS,
  title={Netrin-4 overexpression suppresses primary and metastatic colorectal tumor progression.},
  author={C. Eveno and J O Contreres and Patricia Hainaud and Judith Nemeth and Evelyne Dupuy and Marc Pocard},
  journal={Oncology reports},
  year={2013},
  volume={29 1},
  pages={
          73-8
        }
}
Tumor angiogenesis is closely associated with clinical staging and has been proposed to correlate with clinical response in terms of subsequent metastases following primary resection. Netrin-4 (NT-4) regulates angiogenic responses. Therefore, we sought to examine the effects of NT-4 on the primary tumor growth of colon cancer cells, liver and lung metastases of colon cancer cells, and responses following primary tumor resection. We… 
View on PubMed
spandidos-publications.com
13 Citations
Background Citations
5

13 Citations

Citation Type

Citation Type

NTN4 is associated with breast cancer metastasis via regulation of EMT-related biomarkers.
TLDR
It is demonstrated that NTN4 is reduced in breast cancer tissues and NTN 4 is associated with breast cancer cell migration and invasion via regulation of epithelial mesenchymal transition (EMT)-related biomarkers.
Angiogenesis in liver metastasis of colo-rectal carcinoma.
TLDR
Angiogenesis and treatments avaiable for color-rectal liver metastasis are discussed and diverse pathways and molecules of angiogenesis, especially the VEGF pathway are targeted.
The Netrin-4/ Neogenin-1 axis promotes neuroblastoma cell survival and migration
TLDR
In vivo analysis, using the chicken embryo chorioallantoic membrane (CAM) model, showed that NEO1 and endogenous NTN4 are involved in tumor extravasation and metastasis and collectively demonstrate that endogenousNTN4/NEO1 maintain NB growth via both pro-survival and pro-migratory molecular signaling.
Role of Extracellular Matrix in Gastrointestinal Cancer-Associated Angiogenesis
TLDR
It is envisioned that a deeper understanding of the role of extracellular matrix and of its remodeling during cancer progression is of chief importance for the development of new, more efficacious, targeted therapies.
Netrin-4 promotes mural cell adhesion and recruitment to endothelial cells
TLDR
It is shown that Netrin-4 overexpression improved tumor blood vessel structure and increased VSMC coverage and may play a role in the inhibition of tumor growth.
Animal Models to Test Adjuvant Treatment: An Experimental Model of Colon Cancer
TLDR
An experimental model for use in testing adjuvant treatment of colon cancer using immune-deficient mice is developed and the first results of the model are reported.
Netrin-4 Promotes Differentiation and Migration of Osteoblasts.
TLDR
Netrin-4 promotes differentiation and migration of osteoblasts and was up-regulated during osteoblast differentiation and an RNA interference experiment showed that small interfering RNA used to silence netrin- 4 inhibited osteoblasts differentiation.
New Antiangiogenic Strategies beyond Inhibition of Vascular Endothelial Growth Factor with Special Focus on Axon Guidance Molecules
TLDR
A strong connection to neural development and axon guidance molecules like netrins, Slit proteins, semaphorins, ephrins and their cognate receptors UNC5, Robo1-4, neuropilin and EphB are presented to highlight their value as potential targets for new antiangiogenic therapies.
Netrins and Their Roles in Placental Angiogenesis
TLDR
Among all netrins examined, netrin-4 andNetrin-1 have been found to be either pro- or antiangiogenic factors, which seem to be related to the endothelial cell phenotype studied and seem also to depend on the receptor type to which netrin binds.
Germline Mutations in Familial Papillary Thyroid Cancer
TLDR
Results indicate that these novel genes are seemingly associated with hereditary PTC, but extension and validation in other PTC families are required.
...
1
2
...

References

SHOWING 1-10 OF 34 REFERENCES
Netrin-4 delays colorectal cancer carcinomatosis by inhibiting tumor angiogenesis.
Netrin-1 mediates early events in pancreatic adenocarcinoma progression, acting on tumor and endothelial cells.
TLDR
An in vivo model to analyze interactions between cancer and stromal cells during early stages of Pancreatic ductal adenocarcinoma and silencing of tumor cell NTN1 inhibited tumor cell invasion in vivo was developed to study the invasive mechanisms of early-stage PDAC.
Orthotopic Metastatic Mouse Models for Anticancer Drug Discovery and Evaluation: a Bridge to the Clinic
  • R. Hoffman
  • Biology, Medicine
    Investigational New Drugs
  • 2004
TLDR
Unique clinically-accurate and relevant SOI models of humancancer for antitumor and antimetastatic drug discovery and serve as abridge linking pre-clinical and clinical research and drugdevelopment.
Netrin-4 regulates angiogenic responses and tumor cell growth.
Biological mechanisms of bevacizumab-associated adverse events
TLDR
A number of serious soft-tissue and vascular toxicities have also been observed in patients receiving this anti-angiogenic agent, and the pathogenic mechanisms that lead to the adverse events are proposed.
Neoadjuvant chemotherapy before liver resection for patients with unresectable liver metastases from colorectal carcinoma.
TLDR
The current data on neoadjuvant systemic chemotherapy, the rationale for this approach, potential complications, and future prospects are summarized.
Combined analysis of efficacy: the addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer.
TLDR
The addition of bevacizumab to FU/LV provides a statistically significant and clinically relevant benefit to patients with previously untreated metastatic colorectal cancer.
Drug resistance associated with antiangiogenesis therapy.
Metastasectomy for Stage IV Colorectal Cancer
TLDR
The history and current status of metastasectomy in stage IV colorectal cancer is reviewed, suggesting that a few patients may be cured with resection of these tumors.
Further Pharmacological and Genetic Evidence for the Efficacy of PlGF Inhibition in Cancer and Eye Disease
...
1
2
3
4
...