Netrin-1 mediates early events in pancreatic adenocarcinoma progression, acting on tumor and endothelial cells.

@article{Dumartin2010Netrin1ME,
  title={Netrin-1 mediates early events in pancreatic adenocarcinoma progression, acting on tumor and endothelial cells.},
  author={Laurent Dumartin and Cathy Quemener and Hanane Laklai and John Herbert and Roy Bicknell and Corinne Bousquet and St{\'e}phane Pyronnet and Vincent Castronovo and Martin K. Schilling and Andr{\'e}as Bikfalvi and Martin Hagedorn},
  journal={Gastroenterology},
  year={2010},
  volume={138 4},
  pages={1595-606, 1606.e1-8}
}
BACKGROUND & AIMS Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers. It is characterized by substantial tumor cell invasion and early-stage metastasis. We developed an in vivo model to analyze interactions between cancer and stromal cells during early stages of PDAC. METHODS Human pancreatic adenocarcinoma cells were grafted onto the chick chorioallantoic membrane (CAM). Human and chicken GeneChips were used simultaneously to study gene regulation during PDAC cell… CONTINUE READING

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