Netrin-1 interacts with amyloid precursor protein and regulates amyloid-β production

  title={Netrin-1 interacts with amyloid precursor protein and regulates amyloid-β production},
  author={Filipe Calheiros Lourenço and V. A. Galvan and Joanna Fombonne and V{\'e}ronique Corset and Fabien Llambi and Ulrike M{\"u}ller and Dale E. Bredesen and Patrick Mehlen},
  journal={Cell Death and Differentiation},
The β-amyloid precursor protein (APP) is an orphan transmembrane receptor whose physiological role is largely unknown. APP is cleaved by proteases generating amyloid-β (Aβ) peptide, the main component of the amyloid plaques that are associated with Alzheimer's disease. Here, we show that APP binds netrin-1, a multifunctional guidance and trophic factor. Netrin-1 binding modulates APP signaling triggering APP intracellular domain (AICD)-dependent gene transcription. Furthermore, netrin-1 binding… CONTINUE READING
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