Netrin-1: diversity in development.

  title={Netrin-1: diversity in development.},
  author={Danakai Bradford and Stacey J. Cole and Helen M. Cooper},
  journal={The international journal of biochemistry & cell biology},
  volume={41 3},
In 1990, the discovery of three Caenorhabditis elegans genes (unc5, unc6, unc40) involved in pioneer axon guidance and cell migration marked a significant advancement in neuroscience research [Hedgecock EM, Culotti JG, Hall DH. The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans. Neuron 1990;4:61-85]. The importance of this molecular guidance system was exemplified in 1994, when the vertebrate orthologue of… CONTINUE READING


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