Neto Auxiliary Subunits Regulate Interneuron Somatodendritic and Presynaptic Kainate Receptors to Control Network Inhibition.

@article{Wyeth2017NetoAS,
  title={Neto Auxiliary Subunits Regulate Interneuron Somatodendritic and Presynaptic Kainate Receptors to Control Network Inhibition.},
  author={Megan S. Wyeth and Kenneth A. Pelkey and Xue-Han Yuan and Geoffrey A. Vargish and April D Johnston and Steven A. Hunt and Calvin Fang and Daniel T Abebe and Vivek Mahadevan and Andr{\'e} Fisahn and Michael W. Salter and Roderick R Mcinnes and Ramesh Chittajallu and Chris J McBain},
  journal={Cell reports},
  year={2017},
  volume={20 9},
  pages={2156-2168}
}
Although Netos are considered auxiliary subunits critical for kainate receptor (KAR) function, direct evidence for their regulation of native KARs is limited. Because Neto KAR regulation is GluK subunit/Neto isoform specific, such regulation must be determined in cell-type-specific contexts. We demonstrate Neto1/2 expression in somatostatin (SOM)-, cholecystokinin/cannabinoid receptor 1 (CCK/CB1)-, and parvalbumin (PV)-containing interneurons. KAR-mediated excitation of these interneurons is… CONTINUE READING
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