NetMHCpan, a Method for Quantitative Predictions of Peptide Binding to Any HLA-A and -B Locus Protein of Known Sequence

@article{Nielsen2007NetMHCpanAM,
  title={NetMHCpan, a Method for Quantitative Predictions of Peptide Binding to Any HLA-A and -B Locus Protein of Known Sequence},
  author={Morten Nielsen and Claus Lundegaard and Thomas Blicher and Kasper Lamberth and Mikkel Harndahl and Sune Justesen and Gustav Andreas R\oder and Bjoern Peters and Alessandro Sette and Ole Lund and S\oren Buus},
  journal={PLoS ONE},
  year={2007},
  volume={2},
  pages={477 - 491}
}
BACKGROUND Binding of peptides to Major Histocompatibility Complex (MHC) molecules is the single most selective step in the recognition of pathogens by the cellular immune system. The human MHC class I system (HLA-I) is extremely polymorphic. The number of registered HLA-I molecules has now surpassed 1500. Characterizing the specificity of each separately would be a major undertaking. PRINCIPAL FINDINGS Here, we have drawn on a large database of known peptide-HLA-I interactions to develop a… CONTINUE READING
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