Net renal tubular reabsorption of zinc in healthy man and impaired handling in sickle cell anemia.

@article{YuzbasiyanGurkan1989NetRT,
  title={Net renal tubular reabsorption of zinc in healthy man and impaired handling in sickle cell anemia.},
  author={Vilma Yuzbasiyan-Gurkan and George J. Brewer and Arthur J. Vander and Matthias Guenther and Ananda S. Prasad},
  journal={American journal of hematology},
  year={1989},
  volume={31 2},
  pages={87-90}
}
Zinc deficiency is a significant clinical finding in sickle cell anemia (SCA) and abnormalities of zinc handling such as hyperzincuria are present. The cause of increased urinary zinc excretion in SCA is not clear. To define the renal handling of zinc in SCA and in healthy subjects, we measured zinc (total and ultrafilterable plasma zinc, urine zinc) and creatinine clearance in eight healthy and seven SCA subjects. Ultrafilterable zinc in plasma was assessed by equilibration of plasma with 65Zn… CONTINUE READING

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