Nested Russian Doll-Like Genetic Mobility Drives Rapid Dissemination of the Carbapenem Resistance Gene blaKPC

@inproceedings{Sheppard2016NestedRD,
  title={Nested Russian Doll-Like Genetic Mobility Drives Rapid Dissemination of the Carbapenem Resistance Gene blaKPC},
  author={Anna E. Sheppard and Nicole Stoesser and Daniel J. Wilson and Robert P. Sebra and Andrew Kasarskis and Luke W. Anson and Adam P Giess and Louise J. Pankhurst and Alison Vaughan and Christopher J. Grim and Heather L. Cox and Anthony J. Yeh and Costi D. Sifri and A. Sarah Walker and Tim E. A. Peto and Derrick W. Crook and Amy J Mathers},
  booktitle={Antimicrobial agents and chemotherapy},
  year={2016}
}
The recent widespread emergence of carbapenem resistance in Enterobacteriaceae is a major public health concern, as carbapenems are a therapy of last resort against this family of common bacterial pathogens. Resistance genes can mobilize via various mechanisms, including conjugation and transposition; however, the importance of this mobility in short-term… CONTINUE READING

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