Nest building is a novel method for indexing severity of alcohol withdrawal in mice.

@article{Greenberg2016NestBI,
  title={Nest building is a novel method for indexing severity of alcohol withdrawal in mice.},
  author={Gian D. Greenberg and Lawrence Chung-Long Huang and Stephanie E Spence and Jason P. Schlumbohm and Pamela Metten and Angela R Ozburn and J Christopher F Crabbe},
  journal={Behavioural brain research},
  year={2016},
  volume={302},
  pages={182-90}
}
Withdrawal after chronic ethanol (EtOH) affects body temperature, goal-directed behavior and motor function in mice and increases general central nervous system excitability. Nest-building tests have been used to assay these states but to this point have not been employed as measures of EtOH withdrawal severity. We first refined nest-scoring methods using a genetically heterogeneous stock of mice (HS/Npt). Mice were then made physically dependent following three days of chronic EtOH vapor… CONTINUE READING
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