Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells.

@article{Wilson2015NesprinsAK,
  title={Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells.},
  author={Meredith H. Wilson and Erika L. F. Holzbaur},
  journal={Development},
  year={2015},
  volume={142 1},
  pages={218-28}
}
During skeletal muscle development, nuclei move dynamically through myotubes in a microtubule-dependent manner, driven by the microtubule motor protein kinesin-1. Loss of kinesin-1 leads to improperly positioned nuclei in culture and in vivo. Two models have been proposed to explain how kinesin-1 functions to move nuclei in myotubes. In the cargo model, kinesin-1 acts directly from the surface of the nucleus, whereas in an alternative model, kinesin-1 moves nuclei indirectly by sliding anti… CONTINUE READING