Nesprins: from the nuclear envelope and beyond

  title={Nesprins: from the nuclear envelope and beyond},
  author={Dipen Rajgor and Catherine M Shanahan},
  booktitle={Expert reviews in molecular medicine},
Nuclear envelope spectrin-repeat proteins (Nesprins), are a novel family of nuclear and cytoskeletal proteins with rapidly expanding roles as intracellular scaffolds and linkers. Originally described as proteins that localise to the nuclear envelope (NE) and establish nuclear-cytoskeletal connections, nesprins have now been found to comprise a diverse spectrum of tissue specific isoforms that localise to multiple sub-cellular compartments. Here, we describe how nesprins are necessary in… CONTINUE READING

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Nesprins: from the nuclear envelope and beyond

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