Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton.

@article{Dawe2009Nesprin2IW,
  title={Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton.},
  author={Helen R. Dawe and Matthew R. Adams and Gabrielle Wheway and Katarzyna M. Szymańska and Clare V Logan and Angelika A. Noegel and Keith Gull and Colin A. Johnson},
  journal={Journal of cell science},
  year={2009},
  volume={122 Pt 15},
  pages={2716-26}
}
Meckel-Gruber syndrome (MKS) is a severe autosomal recessively inherited disorder caused by mutations in genes that encode components of the primary cilium and basal body. Here we show that two MKS proteins, MKS1 and meckelin, that are required for centrosome migration and ciliogenesis interact with actin-binding isoforms of nesprin-2 (nuclear envelope… CONTINUE READING