Nesfatin-1 stimulates glucagon and insulin secretion and beta cell NUCB2 is reduced in human type 2 diabetic subjects

@article{Riva2011Nesfatin1SG,
  title={Nesfatin-1 stimulates glucagon and insulin secretion and beta cell NUCB2 is reduced in human type 2 diabetic subjects},
  author={M. Riva and M. Nitert and U. Voss and R. Sathanoori and A. Lindqvist and C. Ling and N. Wierup},
  journal={Cell and Tissue Research},
  year={2011},
  volume={346},
  pages={393-405}
}
  • M. Riva, M. Nitert, +4 authors N. Wierup
  • Published 2011
  • Biology, Medicine
  • Cell and Tissue Research
  • Nesfatin-1 is a novel anorexigenic regulatory peptide. The peptide is the N-terminal part of nucleobindin 2 (NUCB2) and is expressed in brain areas regulating feeding. Outside the brain, nesfatin-1 expression has been reported in adipocytes, gastric endocrine cells and islet cells. We studied NUCB2 expression in human and rodent islets using immunocytochemistry, in situ hybridization and western blot. Furthermore, we investigated the potential influence of nesfatin-1 on secretion of insulin and… CONTINUE READING
    Nesfatin-1 in human and murine cardiomyocytes: synthesis, secretion, and mobilization of GLUT-4.
    47
    Peripheral Effects of Nesfatin-1 on Glucose Homeostasis
    50

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 28 REFERENCES
    Nesfatin-1 exerts a direct, glucose-dependent insulinotropic action on mouse islet β- and MIN6 cells.
    75
    Nutrient responsive nesfatin-1 regulates energy balance and induces glucose-stimulated insulin secretion in rats.
    89
    Identification and characterization of nesfatin-1 immunoreactivity in endocrine cell types of the rat gastric oxyntic mucosa.
    258
    Pancreatic beta cells colocalize insulin and pronesfatin immunoreactivity in rodents.
    130
    Identification of nesfatin-1 as a satiety molecule in the hypothalamus
    717