Nesfatin-1 stimulates glucagon and insulin secretion and beta cell NUCB2 is reduced in human type 2 diabetic subjects

@article{Riva2011Nesfatin1SG,
  title={Nesfatin-1 stimulates glucagon and insulin secretion and beta cell NUCB2 is reduced in human type 2 diabetic subjects},
  author={Matteo Dalla Riva and Marloes Dekker Nitert and Ulrikke Voss and Ramasri Sathanoori and Andreas Lindqvist and Charlotte Ling and Nils Wierup},
  journal={Cell and Tissue Research},
  year={2011},
  volume={346},
  pages={393-405}
}
Nesfatin-1 is a novel anorexigenic regulatory peptide. The peptide is the N-terminal part of nucleobindin 2 (NUCB2) and is expressed in brain areas regulating feeding. Outside the brain, nesfatin-1 expression has been reported in adipocytes, gastric endocrine cells and islet cells. We studied NUCB2 expression in human and rodent islets using immunocytochemistry, in situ hybridization and western blot. Furthermore, we investigated the potential influence of nesfatin-1 on secretion of insulin and… CONTINUE READING