Nesfatin-1 promotes brown adipocyte phenotype

  title={Nesfatin-1 promotes brown adipocyte phenotype},
  author={Yuexin Wang and Ziru Li and Xinyu Zhang and Xinxin Xiang and Yin Li and Michael W. Mulholland and Weizhen Zhang},
  booktitle={Scientific reports},
Nesfatin-1, an 82 amino acid gastric peptide, is involved in regulation of food uptake and in multiple metabolic activities. Whether nesfatin-1 modulates the differentiation and lipid metabolism of brown adipocytes remains unknown. In the present study, we found that nesfatin-1 mRNA and protein were detectable in isolated brown adipocytes and gradually decreased during differentiation (95% CI 0.6057 to 1.034, p = 0.0001). The decrease in nesfatin-1 was associated with a significant reduction in… CONTINUE READING
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