Nesfatin-1 in human and murine cardiomyocytes: synthesis, secretion, and mobilization of GLUT-4.

  title={Nesfatin-1 in human and murine cardiomyocytes: synthesis, secretion, and mobilization of GLUT-4.},
  author={S Feij{\'o}o-Band{\'i}n and Diego Rodr{\'i}guez-Penas and Vanessa Garc{\'i}a-R{\'u}a and Ana Mosquera-Leal and Manuel Otero and Eva Pereira and J. Rubio and Isabel Jerez Mart{\'i}nez and Luisa Mar{\'i}a Seoane and Oreste Gualillo and M. Isabel Calaza and Tom{\'a}s Garc{\'i}a-Caballero and Manuel Portol{\'e}s and Esther Rosell{\'o}-Llet{\'i} and Carlos Di{\'e}guez and Miguel Angel Guzman Rivera and Jos{\'e} Ram{\'o}n G{\'o}nzalez-Juanatey and Francisca Lago},
  volume={154 12},
Nesfatin-1, a satiety-inducing peptide identified in hypothalamic regions that regulate energy balance, is an integral regulator of energy homeostasis and a putative glucose-dependent insulin coadjuvant. We investigated its production by human cardiomyocytes and its effects on glucose uptake, in the main cardiac glucose transporter GLUT-4 and in intracellular signaling. Quantitative RT-PCR, Western blots, confocal immunofluorescence microscopy, and ELISA of human and murine cardiomyocytes and… CONTINUE READING


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