Nesfatin-1 functions as a switch for phenotype transformation and proliferation of VSMCs in hypertensive vascular remodeling.

@article{Lu2018Nesfatin1FA,
  title={Nesfatin-1 functions as a switch for phenotype transformation and proliferation of VSMCs in hypertensive vascular remodeling.},
  author={Qing-Bo Lu and Huiping Wang and Zihan Tang and Han Cheng and Qiong Du and Yuan-Ben Wang and Wu-Bing Feng and Ke-Xue Li and Weiwei Cai and Liying Qiu and Hai-Jian Sun},
  journal={Biochimica et biophysica acta. Molecular basis of disease},
  year={2018},
  volume={1864 6 Pt A},
  pages={
          2154-2168
        }
}
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40 Citations
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Background Citations
15
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40 Citations

LncRNA MRAK048635_P1 is critical for vascular smooth muscle cell function and phenotypic switching in essential hypertension
TLDR
It is revealed that decreased MRAK048635_P1 is probably an important factor for vascular remodeling by affecting VSMC cell function and phenotypic switching in essential hypertension.
p22phox promotes Ang-II-induced vascular smooth muscle cell phenotypic switch by regulating KLF4 expression.
Magnolol alleviates hypoxia-induced pulmonary vascular remodeling through inhibition of phenotypic transformation in pulmonary arterial smooth muscle cells.
Role of the signal transducer and activator of transcription 3 protein in the proliferation of vascular smooth muscle cells
TLDR
Studying the mechanism of VSMC proliferation induced by the STAT3 pathway is valuable for finding therapeutic targets for CVD.
Nesfatin-1 suppresses peripheral arterial remodeling without elevating blood pressure in mice
TLDR
Evaluating the vasoprotective and vasopressor effects of nesfatin-1 at different doses in mouse models demonstrated that nesFatin- 1 can be a therapeutic target for improved treatment of peripheral artery disease.
Imperatorin alleviates the abnormal proliferation, migration, and foaming of ox-LDL-induced VSMCs through regulating PI3K/Akt/mTOR signaling pathway
lncRNA 430945 promotes the proliferation and migration of vascular smooth muscle cells via the ROR2/RhoA signaling pathway in atherosclerosis
TLDR
It was found that the expression of lncRNA 430945 was high in human AS tissues, which in turn promoted angiotensin II (AngII)-induced VSMC proliferation and migration and activated the signaling pathways associated with ROR2 and Ras homolog gene family member A (RhoA).
Urantide alleviates the symptoms of atherosclerotic rats in vivo and in vitro models through the JAK2/STAT3 signaling pathway.
Extracellular Vesicle-Mediated Vascular Cell Communications in Hypertension: Mechanism Insights and Therapeutic Potential of ncRNAs
TLDR
The current findings focusing on the emerging roles of extracellular vesicle-carrying ncRNAs in the pathologies of hypertension and its associated vascular remodeling are discussed and highlighted.
Expression of Long Noncoding RNA LIPCAR Promotes Cell Proliferation, Cell Migration, and Change in Phenotype of Vascular Smooth Muscle Cells
TLDR
The data suggest that overexpression of LIPCAR promotes cell proliferation, migration, and phenotypic switch of vascular smooth muscle cells.
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TLDR
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TLDR
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