Nervous system Lyme disease.

@article{Halperin2008NervousSL,
  title={Nervous system Lyme disease.},
  author={John J Halperin},
  journal={Infectious disease clinics of North America},
  year={2008},
  volume={22 2},
  pages={
          261-74, vi
        }
}
  • J. Halperin
  • Published 1 June 2008
  • Medicine
  • Infectious disease clinics of North America

Medically Refractory Neuroborreliosis Case Presented with Coexistance Involvements of Cranial 7 and 8 Nerves

TLDR
A case of persistent neurological deficits as a result of chronic Lyme disease resistant to standard therapy, which is unique due to involvements of cranial seven and eight nerves at the same time.

Lyme Disease Presenting with Multiple Cranial Nerve Deficits: Report of a Case

TLDR
A case of 38-year-old man with Lyme disease presenting with simultaneous palsy of 3rd, 5th, 7th, 9th, and 10th cranial nerves is reported.

Nervous system lyme disease: is there a controversy?

  • J. Halperin
  • Medicine, Psychology
    Seminars in neurology
  • 2011
TLDR
Persistent misconceptions about the role and interpretation of laboratory tests, what is and is not evidence of nervous system infection, and what constitutes an expected response to treatment have fostered widespread perceptions that this disease is highly controversial.

Lyme Neuroborreliosis

TLDR
Clinical aspects of the diagnosis and treatment of Lyme neuroborreliosis, with focus on the United States, are reviewed, finding treatment with recommended antibiotic regimens is effective and patients with early disease usually have excellent outcomes.

Neurologic Complications of Lyme Disease

TLDR
This article reviews the symptomatology, diagnosis, and treatment of neuroborreliosis and concludes that the most common neurologic complications of Lyme disease are cranial neuritis, meningitis, and radiculoneuritis/mononeuropathy multiplex.

Erythema migrans associated with partial Horner's syndrome

TLDR
A case of a 37-year-old woman who presented with partial Horner's syndrome, which was associated with erythema migrans, and other signs of Lyme disease is presented.

A Rare Cause of Optic Neuropathy

TLDR
The case of a 48-year-old male who developed loss of vision in the right eye over a period of two months and a diagnosis of Lyme neuroborreliosis with meningitis and optic neuritis with sequelae of the inflammatory process is presented.

Atypical papillitis: An isolated manifestation of Lyme disease

TLDR
The case is presented of an atypical papillitis, probably caused by the bacterium Borrelia burgdorferi, which should be considered as a possible diagnosis of atypicals optical neuropathies, particularly if it occurs in an endemic area.

Peripheral facial palsy revealing neuroborreliosis

  • Y. BenmohA. M Bourazza A
  • Medicine, Biology
    International Physical Medicine & Rehabilitation Journal
  • 2018
TLDR
The spontaneous evolution of the spirochete is involving the nervous system in a second phase, and the prevalence of Lyme neuroborreliosis is estimated to 85.500 patients annually, with variety from 10 in North Africa to 65.000 patients in Europe.

Central nervous system borreliosis mimicking a pontine tumour.

TLDR
The case of a 10-year-old girl with neuroborreliosis mimicking a space-occupying lesion in the brainstem, without any previously recognized manifestations of borreliosis, is reported.
...

References

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The triad of neurologic manifestations of Lyme disease

TLDR
Although sometimes incomplete, the triad of neurologic manifestations of Lyme disease— meningitis, cranial neuritis, and radiculoneuritis—presents a unique clinical picture.

Lyme disease of the brainstem

TLDR
Lyme disease involvement of the cerebellar peduncles with hypermetabolism on PET is described, which is the primary imaging modality for most suspected CNS pathology in patients with suspected Lyme disease.

Lyme borreliosis in Bell's palsy

TLDR
Rarely, the palsy may occur prior to the development of a measurable antibody response, indicating a need for follow-up serologic testing.

ANTIBIOTIC RESPONSIVE DEMYELINATING NEUROPATHY RELATED TO LYME DISEASE

TLDR
A patient who developed a demyelinating neuropathy in the context of Lyme disease led to marked clinical and electrophysiologic recovery, suggesting an infectious rather than an immune-mediated pathogenesis.

Lyme neuroborreliosis. Peripheral nervous system manifestations.

TLDR
It is concluded that reversible PNS abnormalities occur in one-third of patients with late Lyme borreliosis, and the pattern of electrophysiological abnormalities is the same in all and is indicative of widespread axonal damage, suggesting that these different presentations reflect varying manifestations of the same pathological process.

Is the presence of antibodies in CSF sufficient to make a definitive diagnosis of Lyme disease?

In clinical practice, the possibility of neurologic Lyme disease is raised by physicians during tick season in endemic regions in patients with headache, meningismus, seventh cranial nerve palsies,

CNS‐borreliosis selectively affecting central motor neurons

TLDR
D diagnosis was based on elevated B. burgdorferi IgG antibody titers in cerebrospinal fluid and titer normalization at clinical recovery, favouring the hypothesis of the presence of the organism within the CNS.

The Long-Term Clinical Outcomes of Lyme Disease: A Population-Based Retrospective Cohort Study

TLDR
The prevalence of persistent symptoms in unselected patients with a history of Lyme disease was ascertained; their rheumatologic, neurologic, and health status outcomes were determined; and potential risk factors for these long-term sequelae were identified.

Lyme borreliosis‐associated encephalopathy

TLDR
CSF is studied in 73 patients referred for presumed CNS Lyme to conclude that CNS infection with B burgdorferi does occur in a small proportion of seropositive patients with this confusional state but is extremely uncommon among seronegative individuals with this clinical presentation.

Chronic neurologic manifestations of Lyme disease.

TLDR
Month to years after the initial infection with B. burgdorferi, patients with Lyme disease may have chronic encephalopathy, polyneuropathy, or less commonly, leukoencephalitis, which usually improve with antibiotic therapy.
...