Nerve stimulation-induced nitric oxide release as a consequence of muscarinic M1 receptor activation.

@article{Iversen1997NerveSN,
  title={Nerve stimulation-induced nitric oxide release as a consequence of muscarinic M1 receptor activation.},
  author={Hanne Iversen and Nils Peter Wiklund and C. Olgart and Lars E. Gustafsson},
  journal={European journal of pharmacology},
  year={1997},
  volume={331 2-3},
  pages={213-9}
}
The aim of the present study was to investigate whether nerve stimulation-induced nitric oxide (NO) release in the guinea-pig colon is affected by acetylcholine and to identify the muscarinic receptor subtype involved. Nerve-smooth muscle preparations were suspended in a superfusion chamber and NO/NO2- overflow in the superfusate was detected by chemiluminescence analysis. Transmural nerve stimulation evoked a significant increase in NO/NO2- release, which was inhibited by N(omega)-nitro-L… CONTINUE READING
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