Nerve regeneration in predegenerated basal lamina graft: the effect of duration of predegeneration on axonal extension.

@article{Ochi1994NerveRI,
  title={Nerve regeneration in predegenerated basal lamina graft: the effect of duration of predegeneration on axonal extension.},
  author={Masami Ochi and Motomi Wakasa and Yoshikazu Ikuta and Wai Hang Kwong},
  journal={Experimental neurology},
  year={1994},
  volume={128 2},
  pages={216-25}
}
We used predegenerated acellular grafts to bridge proximal and distal stumps of transected nerves and studied how the duration of predegeneration might affect axonal regeneration. Predegenerated acellular grafts were prepared by transecting the tibial nerve of donor rats and, after a period of degeneration, freeze-thawing a 40-mm long segment of the distal stump. Five degeneration periods were used: 0 days (for fresh grafts), 3 days, 1 week, 4 weeks, and 8 weeks. Fresh cellular grafts not… CONTINUE READING