Nerve injury induces robust allodynia and ectopic discharges in Nav1.3 null mutant mice

@article{Nassar2006NerveII,
  title={Nerve injury induces robust allodynia and ectopic discharges in Nav1.3 null mutant mice},
  author={Mohammed A. Nassar and Mark D Baker and Alessandra Levato and Rachel A Ingram and Giovanna R Mallucci and Stephen B. McMahon and John N Wood},
  journal={Molecular Pain},
  year={2006},
  volume={2},
  pages={33 - 33}
}
Changes in sodium channel activity and neuronal hyperexcitability contribute to neuropathic pain, a major clinical problem. There is strong evidence that the re-expression of the embryonic voltage-gated sodium channel subunit Nav1.3 underlies neuronal hyperexcitability and neuropathic pain. Here we show that acute and inflammatory pain behaviour is unchanged in global Nav1.3 mutant mice. Surprisingly, neuropathic pain also developed normally in the Nav1.3 mutant mouse. To rule out any genetic… CONTINUE READING