Nerve injury-induced changes in Homer/glutamate receptor signaling contribute to the development and maintenance of neuropathic pain

@article{Obara2013NerveIC,
  title={Nerve injury-induced changes in Homer/glutamate receptor signaling contribute to the development and maintenance of neuropathic pain},
  author={Ilona Obara and Scott Philip Goulding and Jia-hua Hu and Matthias Klugmann and Karen K Szumlinski},
  journal={PAIN®},
  year={2013},
  volume={154},
  pages={1932-1945}
}
While group 1 metabotropic glutamate receptors (mGluRs) and ionotropic N-methyl-d-aspartate (NMDA) receptors regulate nociception, the precise molecular mechanism(s) contributing to glutamate signaling in chronic pain remain unclear. Here we not only confirmed the key involvement of Homer proteins in neuropathic pain, but also distinguished between the functional roles for different Homer family members and isoforms. Chronic constriction injury (CCI) of the sciatic nerve induced long-lasting… CONTINUE READING
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