Nerve-induced ectopic limb blastemas in the Axolotl are equivalent to amputation-induced blastemas.

@article{Satoh2007NerveinducedEL,
  title={Nerve-induced ectopic limb blastemas in the Axolotl are equivalent to amputation-induced blastemas.},
  author={Akira Satoh and David M. Gardiner and Susan V. Bryant and Tetsuya Endo},
  journal={Developmental biology},
  year={2007},
  volume={312 1},
  pages={231-44}
}
Adult urodeles (salamanders) are unique in their ability to regenerate complex organs perfectly. The recently developed Accessory Limb Model (ALM) in the axolotl provides an opportunity to identify and characterize the essential signaling events that control the early steps in limb regeneration. The ALM demonstrates that limb regeneration progresses in a stepwise fashion that is dependent on signals from the wound epidermis, nerves and dermal fibroblasts from opposite sides of the limb. When… CONTINUE READING

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