Nerve guides seeded with autologous schwann cells improve nerve regeneration.

  title={Nerve guides seeded with autologous schwann cells improve nerve regeneration.},
  author={Francisco J. Rodr{\'i}guez and Enrique Verd{\'u} and Dolores Ceballos and Xavier Navarro},
  journal={Experimental neurology},
  volume={161 2},
This study evaluates the ability of Schwann cells (SCs) transplanted into a nerve guide to improve regeneration and reinnervation after sciatic nerve resection and repair, leaving a 6-mm gap, in the mouse. SCs were isolated from predegenerated adult sciatic nerves and expanded in culture using a chemically defined medium. Syngeneic, isogeneic, and autologous SCs were suspended in Matrigel and seeded in resorbable, permeable poly(l-lactide-co-epsilon-caprolactone) guides at 150,000 cells/tube… CONTINUE READING


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