Nerve growth factor survival signaling in cultured hippocampal neurons is mediated through TrkA and requires the common neurotrophin receptor P75.

@article{Culmsee2002NerveGF,
  title={Nerve growth factor survival signaling in cultured hippocampal neurons is mediated through TrkA and requires the common neurotrophin receptor P75.},
  author={Carsten Culmsee and Norbert Gerling and Mario Lehmann and Mariana N. Nikolova-Karakashian and Jochen H. M. Prehn and Mark P. Mattson and Josef Krieglstein},
  journal={Neuroscience},
  year={2002},
  volume={115 4},
  pages={1089-108}
}
The role of the common neurotrophin receptor p75 (p75NTR) in neuronal survival and cell death remains controversial. On the one hand, p75NTR provides a positive modulatory influence on nerve growth factor (NGF) signaling through the high affinity neurotrophin receptor TrkA, and hence increases NGF survival signaling. However, p75NTR may also signal independently of TrkA, causing cell death or cell survival, depending on the cell type and stage of development. Here we demonstrate that TrkA is… CONTINUE READING

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