Nerve growth factor stimulates MMP-2 expression and activity and increases invasion by human pancreatic cancer cells


Pancreatic cancer frequently invades and migrates along neural tissue. Although the exact mechanisms are unknown, perineural invasion negatively impacts prognosis for pancreatic cancer patients. Matrix metalloproteinases (MMPs) are overexpressed in pancreatic cancer and are associated with poor prognosis. We hypothesized that nerve growth factor (NGF… (More)
DOI: 10.1023/B:CLIN.0000046131.24625.54


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