Nerve growth factor specifically induces human IgG4 production.

  title={Nerve growth factor specifically induces human IgG4 production.},
  author={Hajime Kimata and Akihiro Yoshida and Chikashi Ishioka and Takashi Kusunoki and Shinji Hosoi and Haruki Mikawa},
  journal={European journal of immunology},
  volume={21 1},
The effect of nerve growth factor (NGF) on human IgG4 production was studied. NGF specifically enhanced IgG4 production in cultures of human tonsillar mononuclear cells without affecting production of other isotypes or other IgG subclasses. Optimal enhancement of IgG4 production by NGF required the presence of T cells. However, NGF induced significant IgG4 production by small resting B cells in the absence of T cells, and this production was enhanced by stimulation with Staphylococcus aureus… CONTINUE READING