Nerve growth factor signaling, neuroprotection, and neural repair.

  title={Nerve growth factor signaling, neuroprotection, and neural repair.},
  author={Michael V Sofroniew and Charles L Howe and William C Mobley},
  journal={Annual review of neuroscience},
Nerve growth factor (NGF) was discovered 50 years ago as a molecule that promoted the survival and differentiation of sensory and sympathetic neurons. Its roles in neural development have been characterized extensively, but recent findings point to an unexpected diversity of NGF actions and indicate that developmental effects are only one aspect of the biology of NGF. This article considers expanded roles for NGF that are associated with the dynamically regulated production of NGF and its… CONTINUE READING
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