Nerve growth factor selectively decreases activity-dependent conduction slowing in mechano-insensitive C-nociceptors

@article{Obreja2011NerveGF,
  title={Nerve growth factor selectively decreases activity-dependent conduction slowing in mechano-insensitive C-nociceptors},
  author={Otilia Obreja and Matthias Ringkamp and Brian P. Turnquist and Michael Hirth and Martin Schmelz},
  journal={PAIN},
  year={2011},
  volume={152},
  pages={2138-2146}
}
Nerve growth factor (NGF) induces acute sensitization of nociceptive sensory endings and long-lasting hyperalgesia. NGF modulation of sodium channel expression might contribute to neurotrophin-induced hyperalgesia. Here, we investigated NGF-evoked changes of the activity-dependent slowing of conduction in porcine C-fibers. Animals received intradermal injections of NGF (2 μg or 8 μg) or saline in both hind limbs. Extracellular recordings from the saphenous nerves were performed 1 week later… CONTINUE READING

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