Nerve growth factor receptor signaling in proliferation of normal adult rat chromaffin cells

@article{Powers1999NerveGF,
  title={Nerve growth factor receptor signaling in proliferation of normal adult rat chromaffin cells},
  author={James F. Powers and Mehzad Shahsavari and Panayiotis Tsokas and Arthur S. Tischler},
  journal={Cell and Tissue Research},
  year={1999},
  volume={295},
  pages={21-32}
}
Adult rat chromaffin cells may proliferate or extend neurites when stimulated by nerve growth factor (NGF) but their response is predominantly proliferative, making them a unique model for studying how mitogenic specificity is achieved. We examined contributions of the NGF receptors trk and p75 and of the major NGF signaling pathways to proliferation versus neurite outgrowth. The type of initial NGF response does not correlate with intensity of immunoreactivity for trk or p75. However… CONTINUE READING
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