Nerve growth factor rapidly regulates VGF gene transcription through cycloheximide sensitive and insensitive pathways.

Abstract

Nerve growth factor (NGF) initiates and maintains a regulatory cascade, involving gene induction, which results in the neuronal differentiation of PC12 cells. The VGF gene encodes one of the most rapidly induced neuronal mRNAs identified in NGF-treated PC12 cells [Science, 229 (1985) 393-395; Mol. Cell Biol., 11 (1991) 2335-2349]. In this communication we… (More)

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