Nerve growth factor protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme oxygenase-1 in a phosphatidylinositol 3-kinase-dependent manner.

@article{Salinas2003NerveGF,
  title={Nerve growth factor protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme oxygenase-1 in a phosphatidylinositol 3-kinase-dependent manner.},
  author={M. Pe{\~n}a Salinas and Raquel Diaz and Nader G Abraham and Carlos M Ruiz de Galarreta and Antonio Cuadrado},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 16},
  pages={
          13898-904
        }
}
The survival signal elicited by the phosphatidylinositol 3-kinase (PI3K)/Akt1 pathway has been correlated with inactivation of pro-apoptotic proteins and attenuation of the general stress-induced increase in reactive oxygen species (ROS). However, the mechanisms by which this pathway regulates intracellular ROS levels remain largely unexplored. In this study, we demonstrate that nerve growth factor (NGF) prevents the accumulation of ROS in dopaminergic PC12 cells challenged with the Parkinson's… CONTINUE READING

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