Nerve growth factor promotes the activation of phosphatidylinositol 3-kinase and its association with the trk tyrosine kinase.

@article{Soltoff1992NerveGF,
  title={Nerve growth factor promotes the activation of phosphatidylinositol 3-kinase and its association with the trk tyrosine kinase.},
  author={Stephen P. Soltoff and Stuart Rabin and Lewis C. Cantley and David R Kaplan},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 24},
  pages={
          17472-7
        }
}
We investigated the involvement of phosphatidylinositol 3-kinase (PtdIns 3-kinase) in the initiation of signal transduction by nerve growth factor (NGF) in the rat pheochromocytoma PC12 cell line. PtdIns 3-kinase catalyzes the formation of phosphoinositides with phosphate in the D-3 position of the inositol ring and previously has been found to associate with other activated protein tyrosine kinases, including growth factor receptor tyrosine kinases. Anti-phosphotyrosine immunoprecipitates had… CONTINUE READING
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