Nerve growth factor promotes survival of cultured magnocellular cholinergic neurons from nucleus basalis of Meynert in postnatal rats

@article{Hatanaka1988NerveGF,
  title={Nerve growth factor promotes survival of cultured magnocellular cholinergic neurons from nucleus basalis of Meynert in postnatal rats},
  author={Hiroshi Hatanaka and Itsuko Nihonmatsu and Hiroko Tsukui},
  journal={Neuroscience Letters},
  year={1988},
  volume={90},
  pages={63-68}
}
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40 Citations
Background Citations
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Methods Citations
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Results Citations
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40 Citations

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Citation Type

Nerve Growth Factor Promotes Survival of Cultured Cholinergic Neurons from Nucleus Basalis of Meynert of 2-Week-Old Rats
TLDR
The effects of NGF on the functions of cultured cholinergic neurons of the nucleus basalis of Meynert from postnatal 2-week-old rats is reported on.
Effects of nerve growth factor and basic fibroblast growth factor on survival of cultured septal cholinergic neurons from adult rats
Intracellular Storage and Evoked Release of Acetylcholine from Postnatal Rat Basal Forebrain Cholinergic Neurons in Culture with Nerve Growth Factor
TLDR
It is suggested that NGF could regenerate and sustain the stimulation‐evoked release mechanisms of ACh in cultured cholinergic neurons from postnatal rats.
Nerve-growth-factor-dependent and cell-density-independent survival of septal cholinergic neurons in culture from postnatal rats
Survival-promoting effect of NGF on in vitro septohippocampal neurons with cholinergic and GABAergic phenotypes.
Nerve Growth Factor Increases the Intracellular Content of Acetylcholine in Cultured Septal Neurons from Developing Rats
TLDR
Results suggest that intracellular levels of ACh are likely to be regulated by NGF in a fashion similar to that of the activity levels of the biosynthetic enzyme.
Nerve growth factor promotes survival of retrogradely labeled hippocampus-projecting neurons in the rat basal forebrain in vitro.
Culture of neuronal cells from postnatal rat brain: Application to the study of neurotrophic factors
Quisqualic acid-induced lesion of the nucleus basalis of Meynert in young and aging rats: Plasticity of surviving NGF receptor-positive cholinergic neurons
The role of nerve growth factor receptors in cholinergic basal forebrain degeneration in prodromal Alzheimer disease.
Dysfunction of nerve growth factor (NGF) and its high (TrkA) and low (p75NTR) affinity receptors has been suggested to underlie the selective degeneration of the nucleus basalis (NB) cholinergic…
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References

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Developmental change in the nerve growth factor action from induction of choline acetyltransferase to promotion of cell survival in cultured basal forebrain cholinergic neurons from postnatal rats.
Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections
  • F. Hefti
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1986
TLDR
It is suggested that fimbrial transections resulted in retrograde degeneration of cholinergic septo-hippocampal neurons and that NGF treatment strongly attenuated this lesion-induced degeneration.
Septal cholinergic neurons from postnatal rat can survive in the dissociate culture conditions in the presence of nerve growth factor
Differential effects of nerve-growth factor and glioma-conditioned medium on neurons cultured from various regions of fetal rat central nervous system
Dissociated cell culture of cholinergic neurons from nucleus basalis of Meynert and other basal forebrain nuclei.
TLDR
Large cholinergic cells (average diameter, 20-25 micron) were revealed in these cultures, and about 75% of large neurons (20 micron or larger in diameter) were Cholinergic.
Nerve growth factor increases choline acetyl-transferase but not survival or fiber outgrowth of cultured fetal septal cholinergic neurons
Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection.
  • L. Williams, S. Varon, F. Gage
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1986
TLDR
It is reported here that NGF treatment significantly reduces both the total neuronal and cholinergic neuronal death found 2 weeks after fimbria fornix transection; there was a sparing of 50% of the neurons in the MS and essentially 100% of those in the VDB that otherwise would have died.
Localization of nerve growth factor receptors in cholinergic neurons of the human basal forebrain
NGF-mediated increase of choline acetyltransferase (ChAT) in the neonatal rat forebrain: evidence for a physiological role of NGF in the brain?
Nerve growth factor treatment after brain injury prevents neuronal death.
Cholinergic neuronal degeneration after axotomy has been proposed to be due to the loss of a retrogradely transported neurotrophic factor, possibly nerve growth factor (NGF). To test this hypothesis,…
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