Nerve growth factor promotes survival of cultured magnocellular cholinergic neurons from nucleus basalis of Meynert in postnatal rats

@article{Hatanaka1988NerveGF,
  title={Nerve growth factor promotes survival of cultured magnocellular cholinergic neurons from nucleus basalis of Meynert in postnatal rats},
  author={Hiroshi Hatanaka and Itsuko Nihonmatsu and Hiroko Tsukui},
  journal={Neuroscience Letters},
  year={1988},
  volume={90},
  pages={63-68}
}
Nerve Growth Factor Promotes Survival of Cultured Cholinergic Neurons from Nucleus Basalis of Meynert of 2-Week-Old Rats
TLDR
The effects of NGF on the functions of cultured cholinergic neurons of the nucleus basalis of Meynert from postnatal 2-week-old rats is reported on.
Intracellular Storage and Evoked Release of Acetylcholine from Postnatal Rat Basal Forebrain Cholinergic Neurons in Culture with Nerve Growth Factor
TLDR
It is suggested that NGF could regenerate and sustain the stimulation‐evoked release mechanisms of ACh in cultured cholinergic neurons from postnatal rats.
Nerve Growth Factor Increases the Intracellular Content of Acetylcholine in Cultured Septal Neurons from Developing Rats
TLDR
Results suggest that intracellular levels of ACh are likely to be regulated by NGF in a fashion similar to that of the activity levels of the biosynthetic enzyme.
Culture of neuronal cells from postnatal rat brain: Application to the study of neurotrophic factors
The role of nerve growth factor receptors in cholinergic basal forebrain degeneration in prodromal Alzheimer disease.
Dysfunction of nerve growth factor (NGF) and its high (TrkA) and low (p75NTR) affinity receptors has been suggested to underlie the selective degeneration of the nucleus basalis (NB) cholinergic
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TLDR
It is suggested that fimbrial transections resulted in retrograde degeneration of cholinergic septo-hippocampal neurons and that NGF treatment strongly attenuated this lesion-induced degeneration.
Dissociated cell culture of cholinergic neurons from nucleus basalis of Meynert and other basal forebrain nuclei.
TLDR
Large cholinergic cells (average diameter, 20-25 micron) were revealed in these cultures, and about 75% of large neurons (20 micron or larger in diameter) were Cholinergic.
Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection.
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  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
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TLDR
It is reported here that NGF treatment significantly reduces both the total neuronal and cholinergic neuronal death found 2 weeks after fimbria fornix transection; there was a sparing of 50% of the neurons in the MS and essentially 100% of those in the VDB that otherwise would have died.
Nerve growth factor treatment after brain injury prevents neuronal death.
Cholinergic neuronal degeneration after axotomy has been proposed to be due to the loss of a retrogradely transported neurotrophic factor, possibly nerve growth factor (NGF). To test this hypothesis,
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