Nerve growth factor promotes reparative angiogenesis and inhibits endothelial apoptosis in cutaneous wounds of Type 1 diabetic mice

@article{Graiani2004NerveGF,
  title={Nerve growth factor promotes reparative angiogenesis and inhibits endothelial apoptosis in cutaneous wounds of Type 1 diabetic mice},
  author={Galliam Graiani and Costanza Emanueli and Elisa Desortes and Sophie Van Linthout and Antonio Pinna and Carlos D. Figueroa and Luigi Manni and Paolo Madeddu},
  journal={Diabetologia},
  year={2004},
  volume={47},
  pages={1047-1054}
}
The neurotrophin nerve growth factor (NGF) is pro-angiogenic and facilitates wound repair. The present study was conducted to (i) assess the statement of NGF system components in diabetic wounds and (ii) evaluate whether NGF supplementation could prevent impairment of wound neoangiogenesis by diabetes. Skin wounds were produced in the interscapular region of streptozotocin-induced diabetic mice. NGF (1 µg per day in PBS) or vehicle was applied onto the ulcers for 3 days after punching. Non… CONTINUE READING