Nerve growth factor promotes corneal healing: structural, biochemical, and molecular analyses of rat and human corneas.

@article{Lambiase2000NerveGF,
  title={Nerve growth factor promotes corneal healing: structural, biochemical, and molecular analyses of rat and human corneas.},
  author={Alessandro Lambiase and Luigi Manni and Sergio Bonini and P Rama and Alessandra Micera and Luigi Aloe},
  journal={Investigative ophthalmology & visual science},
  year={2000},
  volume={41 5},
  pages={
          1063-9
        }
}
PURPOSE A recent clinical report demonstrated that topical nerve growth factor (NGF) treatment in patients affected by corneal neurotrophic ulcers induced epithelial and stromal healing restoring corneal integrity. Mechanisms(s) undergoing these clinical NGF actions are still unclear. The aim of this study was to investigate the role of NGF in human and rat cornea physiopathology. METHODS Expression of high-affinity NGF receptors, NGF-mRNA, and NGF protein was evaluated in human and rat… CONTINUE READING

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