Nerve growth factor prevents the death and stimulates the neuronal differentiation of clonal PC12 pheochromocytoma cells in serum-free medium

@article{Greene1978NerveGF,
  title={Nerve growth factor prevents the death and stimulates the neuronal differentiation of clonal PC12 pheochromocytoma cells in serum-free medium},
  author={L F Greene},
  journal={The Journal of Cell Biology},
  year={1978},
  volume={78},
  pages={747 - 755}
}
  • L F Greene
  • Published 1978 in The Journal of cell biology
The PC12 clone is a noradrenergic cell line derived from a rat pheochromocytoma. In culture medium containing horse serum, PC12 cells undergo mitosis; when nerve growth factor (NGF) is included in the medium, the cells cease multiplication and extend neuritis. It is shown here: (a) that PC12 cells are not viable in serum-free medium. When serum is withdrawn… CONTINUE READING