Nerve growth factor mediates hyperalgesia and cachexia in auto-immune arthritis

@article{Shelton2005NerveGF,
  title={Nerve growth factor mediates hyperalgesia and cachexia in auto-immune arthritis},
  author={David Louis Shelton and J{\"o}rg Zeller and W H Ho and Jaume Pons and Arnon Rosenthal},
  journal={Pain},
  year={2005},
  volume={116},
  pages={8-16}
}
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NGF seems to play a critical role in models of established neuropathic and inflammatory pain in both rats and mice, with no development of tolerance to antagonism and antagonists of NGF, such as fully human monoclonal anti-NGF antibodies, may have therapeutic utility in analogous human pain conditions.
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The role of nerve growth factor (NGF) in pain generation, relationship between NGF and OA pain, and pathogenic factors involved in OA development are presented and four categories of drugs that target NGF/tropomyosin receptor kinase A (TrkA) signaling are summarized.
Collagen-induced arthritis as a model of hyperalgesia
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This study shows that the CIA model is suitable for testing not only antiinflammatory but also analgesic drugs for potential use in RA, and highlights the importance of using appropriate disease models to assess relevant pain pathways.
Keratinocyte expression of inflammatory mediators plays a crucial role in substance P-induced acute and chronic pain
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The data indicate that SP acting through NK1 receptors supports the nociceptive and vascular components of CRPS, but not the bone-related changes.
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TLDR
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The role of nerve growth factor in a model of visceral inflammation
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It is reported here that the synovium of transgenic arthritic mice expressing human tumour necrosis factor (TNF) contains numerous mast cells (MC) and that their appearance is a phenomenon which was correlated to the local increase in NGF level.
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TLDR
It is shown that administration of trkA-IgG produces a sustained thermal and chemical hypoalgesia and leads to a downregulation of the sensory neuropeptide CGRP (calcitonin gene-related peptide) in treated sensory neurons, suggesting that Antagonists of NGF may be of clinical use in treating some chronic pain states.
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