Nerve growth factor mediates hyperalgesia and cachexia in auto-immune arthritis

@article{Shelton2005NerveGF,
  title={Nerve growth factor mediates hyperalgesia and cachexia in auto-immune arthritis},
  author={David Louis Shelton and J{\"o}rg Zeller and W H Ho and Jaume Pons and Arnon Rosenthal},
  journal={Pain},
  year={2005},
  volume={116},
  pages={8-16}
}
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109 Citations
Highly Influential Citations
8
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41
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2
Results Citations
7

109 Citations

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Citation Type

Nerve Growth Factor Links Oral Cancer Progression, Pain, and Cachexia
TLDR
It is shown that NGF blockade decreased tumor proliferation, nociception, and weight loss by orchestrating proinflammatory cytokines and leptin production, and identified NGF as a common link among proliferation, pain, and cachexia in oral cancer.
The anti-NGF antibody muMab 911 both prevents and reverses pain behaviour and subchondral osteoclast numbers in a rat model of osteoarthritis pain
Antagonism of Nerve Growth Factor-TrkA Signaling and the Relief of Pain
TLDR
Mechanisms by which NGF activation of its cognate receptor, tropomyosin-related kinase A receptor, regulates a host of ion channels, receptors, and signaling molecules to enhance acute and chronic pain are outlined.
Collagen-induced arthritis as a model of hyperalgesia: functional and cellular analysis of the analgesic actions of tumor necrosis factor blockade.
TLDR
This study shows that the CIA model is suitable for testing not only antiinflammatory but also analgesic drugs for potential use in RA, and highlights the importance of using appropriate disease models to assess relevant pain pathways.
Nerve growth factor in rheumatic diseases.
NGF and Its Receptor System
TLDR
The role of NGF and its receptor system in psoriatic disease, inflammatory arthritis, and arthritic pain of osteoarthritis is discussed.
Antibodies to Nerve Growth Factor Reverse Established Tactile Allodynia in Rodent Models of Neuropathic Pain without Tolerance
TLDR
NGF seems to play a critical role in models of established neuropathic and inflammatory pain in both rats and mice, with no development of tolerance to antagonism and antagonists of NGF, such as fully human monoclonal anti-NGF antibodies, may have therapeutic utility in analogous human pain conditions.
Mechanism and therapeutic effectiveness of nerve growth factor in osteoarthritis pain
TLDR
The role of nerve growth factor (NGF) in pain generation, relationship between NGF and OA pain, and pathogenic factors involved in OA development are presented and four categories of drugs that target NGF/tropomyosin receptor kinase A (TrkA) signaling are summarized.
Collagen-induced arthritis as a model of hyperalgesia
TLDR
This study shows that the CIA model is suitable for testing not only antiinflammatory but also analgesic drugs for potential use in RA, and highlights the importance of using appropriate disease models to assess relevant pain pathways.
Keratinocyte expression of inflammatory mediators plays a crucial role in substance P-induced acute and chronic pain
TLDR
The data indicate that SP acting through NK1 receptors supports the nociceptive and vascular components of CRPS, but not the bone-related changes.
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References

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Cachexia in rheumatoid arthritis.
Nerve growth factor contributes to the generation of inflammatory sensory hypersensitivity
The synovium of transgenic arthritic mice expressing human tumor necrosis factor contains a high level of nerve growth factor.
TLDR
It is demonstrated that arthritic transgenic mice which carry and express the human TNF gene also express elevated levels of NGF, and that subcutaneous injection of N GF-antibodies attenuates the loss of body weight caused by the development of disease in these mice.
The role of nerve growth factor in a model of visceral inflammation
Level of nerve growth factor and distribution of mast cells in the synovium of tumour necrosis factor transgenic arthritic mice.
TLDR
It is reported here that the synovium of transgenic arthritic mice expressing human tumour necrosis factor (TNF) contains numerous mast cells (MC) and that their appearance is a phenomenon which was correlated to the local increase in NGF level.
Contribution of interleukin‐1β to the inflammation‐induced increase in nerve growth factor levels and inflammatory hyperalgesia
TLDR
It is demonstrated that IL‐1β contributes to the upregulation of NGF during inflammation and that NGF has a major role in the production of inflammatory pain hypersensitivity.
Role of nerve growth factor in the trinitrobenzene sulfonic acid-induced colonic hypersensitivity
Effect of NGF antibodies on mast cell distribution, histamine and substance P levels in the knee joint of TNF-arthritic transgenic mice
We have previously shown an increase in nerve growth factor (NGF) levels and in mast cell (MC) distribution in the synovium of patients affected by rheumatoid arthritis. We now report that purified…
Nerve growth factor evokes hyperalgesia in mice lacking the low-affinity neurotrophin receptor p75
The biological effects of endogenous nerve growth factor on adult sensory neurons revealed by a trkA-IgG fusion molecule
TLDR
It is shown that administration of trkA-IgG produces a sustained thermal and chemical hypoalgesia and leads to a downregulation of the sensory neuropeptide CGRP (calcitonin gene-related peptide) in treated sensory neurons, suggesting that Antagonists of NGF may be of clinical use in treating some chronic pain states.
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