Nerve growth factor mediated SH2-Bbeta/Akt signal pathway activated in allergic airway challenge in mice.

BACKGROUND AND OBJECTIVE Nerve growth factor (NGF) contributes to airway inflammation and bronchoconstriction in allergic asthma. The Src homology 2beta/serine/threonine kinase (SH2-Bbeta/Akt) pathway is one of the avenues through which NGF regulates the biological activity of pheochromocytoma (PC)12 cells. It has also been reported that NGF upregulates the… CONTINUE READING