Nerve growth factor-induced differentiation of PC12 cells: evaluation of changes in RNA and DNA metabolism.

The relationship between both DNA and RNA metabolism and the nerve growth factor (betaNGF)-induced differentiation of PC12 cells was investigated. Cells remained in log phase growth for 4 days after exposure to betaNGF. DNA synthesis was similarly unaffected by betaNGF during this time. Thereafter, a gradual decrease in DNA synthesis was observed. In… CONTINUE READING