Nerve growth factor increases the sensitivity to zinc toxicity and induces cell cycle arrest in PC12 cells

@article{SnchezMartn2010NerveGF,
  title={Nerve growth factor increases the sensitivity to zinc toxicity and induces cell cycle arrest in PC12 cells},
  author={Francisco Javier S{\'a}nchez-Mart{\'i}n and Elvira Valera and Ilda Casimiro and J. Montada Merino},
  journal={Brain Research Bulletin},
  year={2010},
  volume={81},
  pages={458-466}
}
Zinc is a basic trace element that plays important roles in brain and, consequently, its homeostasis needs to be critically controlled. High zinc concentrations in the interneuron synaptic space may induce neuronal death through mechanisms still partially solved. Undifferentiated pheochromocytoma (PC12) cells have been used to study zinc toxicity. As these cells can be differentiated into neuronal-like cells, the results obtained from differentiated cultures are more useful to understand zinc… CONTINUE READING
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