Nerve growth factor increases mRNA levels for the prion protein and the beta-amyloid protein precursor in developing hamster brain.

@article{Mobley1988NerveGF,
  title={Nerve growth factor increases mRNA levels for the prion protein and the beta-amyloid protein precursor in developing hamster brain.},
  author={William C Mobley and Rachael Lee Neve and Stanley B Prusiner and Mark J McKinley},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1988},
  volume={85 24},
  pages={9811-5}
}
Deposition of amyloid filaments serves as a pathologic hallmark for some neurodegenerative disorders. The prion protein (PrP) is found in amyloid of animals with scrapie and humans with Creutzfeldt-Jakob disease; the beta protein is present in amyloid deposits in Alzheimer disease and Down syndrome patients. These two proteins are derived from precursors that in the brain are expressed primarily in neurons and are membrane bound. We found that gene expression for PrP and the beta-protein… CONTINUE READING