Nerve growth factor increases choline acetyltransferase activity in developing basal forebrain neurons.

@article{Mobley1986NerveGF,
  title={Nerve growth factor increases choline acetyltransferase activity in developing basal forebrain neurons.},
  author={William C Mobley and Julia Lynn Rutkowski and Gihan I. Tennekoon and J Gemski and Kenneth Buchanan and Michael V Johnston},
  journal={Brain research},
  year={1986},
  volume={387 1},
  pages={
          53-62
        }
}
Nerve growth factor (NGF) is a neuronotrophic protein. Its effects on developing peripheral sensory and sympathetic neurons have been extensively characterized, but it is not clear whether NGF plays a role during the development of central nervous system neurons. To address this point, we examined the effect of NGF on the activity of neurotransmitter enzymes in several brain regions. Intracerebroventricular injections of highly purified mouse NGF had a marked effect on the activity of choline… CONTINUE READING

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