Nerve growth factor improves spatial learning and restores hippocampal cholinergic fibers in rats withdrawn from chronic treatment with ethanol

@article{Lukoyanov2002NerveGF,
  title={Nerve growth factor improves spatial learning and restores hippocampal cholinergic fibers in rats withdrawn from chronic treatment with ethanol},
  author={N. Lukoyanov and P. A. Pereira and M. Paula-Barbosa and A. Cadete-Leite},
  journal={Experimental Brain Research},
  year={2002},
  volume={148},
  pages={88-94}
}
  • N. Lukoyanov, P. A. Pereira, +1 author A. Cadete-Leite
  • Published 2002
  • Chemistry, Medicine
  • Experimental Brain Research
  • Abstract. The cholinergic septohippocampal pathway has long been known to be important for learning and memory. Prolonged intake of ethanol causes enduring memory deficits, which are paralleled by partial depletion of hippocampal cholinergic afferents. We hypothesized that exogenous supply of nerve growth factor (NGF), known to serve as a trophic substance for septal cholinergic neurons, can revert the ethanol-induced changes in the septohippocampal cholinergic system. Adult rats were given a… CONTINUE READING
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